HORDB

ID: hor001548
Uniprot ID: Q9DGD4
Protein name: Gonadotropin inhibitory hormone-related peptide 1
Gene name: GNIH
Organism: Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Family: FARP (FMRFamide related peptide) family
Source: Animal
Expression: Specifically expressed in the diencephalon.
Disease: NA
Comments: NA
Taxonomy: Coturnix (genus), Perdicinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: VPNSVANLPLRF
Length: 12(84-95)
Propeptide: MEIISTQKFILLTLATVAFLTPHGACLDELMKSSLESREDDDDKYYETKDSILEEKQRSLNFEEMKDWGSKNFMKVNTPTVNKVPNSVANLPLRFGRSNPEERSIKPSAYLPLRFGRAFGESLSRRAPNLSNRSGRSPLARSSIQSLLNLSQRFGKSVPISLSQGVQESEPGM
Signal peptide: MEIISTQKFILLTLATVAFLTPHGAC
Modification: T12 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Hypothalamic factor, responsible for the negative regulation of gonadotropin secretion.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P11384-F1.pdb

hor001548_AF2.pdb

hor001548_ESM.pdb

Mass:	152294	Formula:	C61H99N17O16
Absent amino acids:	CDEGHIKMQTWY	Common amino acids:	LNPV
pI:	10.55	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	6
Hydrophobicity:	42.5	Boman Index:	-889
Half-Life / Aliphatic Index:	100 hour	Aliphatic Index:	121.67
Instability Index:	5656.67	Extinction Coefficient cystines:	0
Absorbance 280nm:	0